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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2021; 12(11): 1818-1831
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1818
Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective
Ya-Ling Chung, Yi-Chou Hou, I-Kuan Wang, Kuo-Cheng Lu, Tzung-Hai Yen
Ya-Ling Chung, Department of Medical Laboratory, Cardinal-Tien Hospital, New Taipei City 231, Taiwan
Yi-Chou Hou, Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City 231, Taiwan
Yi-Chou Hou, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Yi-Chou Hou, Kuo-Cheng Lu, School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan
I-Kuan Wang, Department of Nephrology, China Medical University Hospital, Taichung 404, Taiwan
I-Kuan Wang, College of Medicine, China Medical University, Taichung 404, Taiwan
Kuo-Cheng Lu, Division of Nephrology, Department of Medicine, Fu Jen Catholic University Hospital, New Taipei City 242, Taiwan
Kuo-Cheng Lu, Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
Tzung-Hai Yen, Department of Nephrology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
Tzung-Hai Yen, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Author contributions: Chung YL and Hou YC contributed data collection and manuscript writing; Wang IK contributed data analysis; Lu KC and Yen TH contributed study design and supervision; Chung YL and Hou YC contributed equally to this work; Lu KC and Yen TH also contributed equally.
Supported by Chang Gung Memorial Hospital, Linkou, Taiwan, No. CORPG3K0191 and No. CMRPG3J1051-3.
Conflict-of-interest statement: The authors declare no conflicts of financial interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tzung-Hai Yen, MD, PhD, Doctor, Professor, Department of Nephrology, Chang Gung Memorial Hospital, No. 199 Tung Hwa North Road, Linkou 333, Taiwan. m19570@adm.cgmh.org.tw
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: May 3, 2021
Revised: May 27, 2021
Accepted: September 22, 2021
Article in press: September 22, 2021
Published online: November 15, 2021
Core Tip

Core Tip: Organophosphate may induce acute hyperglycemia by damaging pancreatic cells and result in new-onset diabetes mellitus after chronic exposure to organophosphate compounds. Organophosphate-mediated new-onset diabetes mellitus might be mediated by a polymorphism of paraoxonase-1, which is associated with organophosphate elimination in hepatocytes. Pancreatic beta cell damage, excessive gluconeogenesis, hepatic steatosis, systemic inflammation and possibly sarcopenia all contribute to insulin resistance and therefore hyperglycemia.