Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2021; 12(1): 1-18
Published online Jan 15, 2021. doi: 10.4239/wjd.v12.i1.1
Diabetes-induced changes in cardiac voltage-gated ion channels
Nihal Ozturk, Serkan Uslu, Semir Ozdemir
Nihal Ozturk, Serkan Uslu, Semir Ozdemir, Department of Biophysics, Akdeniz University Faculty of Medicine, Antalya 07058, Turkey
Author contributions: Ozdemir S designed the study and wrote the manuscript; Uslu S and Ozturk N collected the data and drafted the review article.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Semir Ozdemir, PhD, Professor, Department of Biophysics, Akdeniz University Faculty of Medicine, Dumlupınar Boulevard, Antalya 07058, Turkey.
Received: June 25, 2020
Peer-review started: June 25, 2020
First decision: October 23, 2020
Revised: November 5, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: January 15, 2021
Core Tip

Core Tip: Diabetes mellitus is a multisystemic disease that affects many organs. It causes diabetic cardiomyopathy (DCM) in the heart which is a distinctive pathology that occurs independent of vascular complications. In DCM, altered action potential morphology and contractile dysfunction are mostly associated with defective cardiac ion channels such as voltage-gated K+, Na+ and Ca2+ channels. Therefore, with therapeutic agents specific to cardiac ion channels, both arrhythmogenic events and other functional problems can be mitigated in the diabetic heart.