Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2020; 11(7): 280-292
Published online Jul 15, 2020. doi: 10.4239/wjd.v11.i7.280
Islet cell dysfunction in patients with chronic pancreatitis
Ayan Roy, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Dukhabandhu Naik, Pazhanivel Mohan, Biju Pottakkat
Ayan Roy, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Dukhabandhu Naik, Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Pazhanivel Mohan, Department of Medical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Biju Pottakkat, Department of Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Author contributions: Roy A performed the literature search, wrote the first draft and provided intellectual input; Sahoo J and Kamalanathan S conceptualized the work, performed a literature search, supervised the writing, provided intellectual input and critically revised the manuscript; Naik D, Mohan P and Pottakkat B supervised the writing, provided intellectual input and critically revised the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jayaprakash Sahoo, MD, DM, Additional Professor, Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Room No. 5444, 4th Floor, Super-specialty Block, Puducherry 605006, India. jayaprakash.s@jipmer.edu.in
Received: January 7, 2020
Peer-review started: January 7, 2020
First decision: April 3, 2020
Revised: May 2, 2020
Accepted: May 21, 2020
Article in press: May 21, 2020
Published online: July 15, 2020
Core Tip

Core tip: Chronic pancreatitis (CP) is a progressive inflammatory disorder leading to islet cell dysfunction and subsequent development of diabetes. The disease pathology is complex and is characterized by dysregulation of both the islet cells and the incretin axes. The different surgical procedures performed in patients with CP and antihyperglycemic drugs used to treat diabetes associated with CP also affect islet cell function. Diabetes secondary to CP is difficult to treat and contributes to disease morbidity. Newer therapies targeting alpha cell function and beta cell regeneration would be useful in the management of pancreatic diabetes in the near future.