Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2020; 11(5): 193-201
Published online May 15, 2020. doi: 10.4239/wjd.v11.i5.193
Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters
Mihnea-Alexandru Găman, Mirela Elena Epîngeac, Camelia Cristina Diaconu, Amelia Maria Găman
Mihnea-Alexandru Găman, Camelia Cristina Diaconu, "Carol Davila" University of Medicine and Pharmacy, Bucharest 050474, Romania
Mihnea-Alexandru Găman, Department of Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest 022328, Romania
Mirela Elena Epîngeac, Amelia Maria Găman, Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania
Camelia Cristina Diaconu, Internal Medicine Clinic, Clinical Emergency Hospital of Bucharest, Bucharest 014461, Romania
Amelia Maria Găman, Clinic of Hematology, Filantropia City Hospital, Craiova 200143, Romania
Author contributions: Găman AM, Găman MA and Epîngeac ME designed the study; Epîngeac ME, Găman MA and Găman AM collected the data; Epîngeac ME and Găman AM performed the measurements and contributed reagents; Găman MA analysed the data; Găman MA and Epîngeac ME wrote the paper; Găman AM and Diaconu CC critically revised the paper for scientific content; All authors read and approved the final version of the manuscript; Găman MA and Epîngeac ME contributed equally to this work.
Institutional review board statement: The Ethics Committee of the University of Medicine and Pharmacy of Craiova, Craiova, Romania approved the current study (approval number: 40/27.03.2018).
Informed consent statement: All the subjects involved in the current study agreed to partake in the research and gave their written informed consent. All procedures and experiments were carried out in accordance with the national law and the Helsinki Declaration of 1975, as revised in 2008(5).
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
STROBE statement: The authors certify that the manuscript adheres to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mihnea-Alexandru Găman, MD, Doctor, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest 050474, Romania. mihneagaman@yahoo.com
Received: January 1, 2020
Peer-review started: January 1, 2020
First decision: January 15, 2020
Revised: March 24, 2020
Accepted: March 28, 2020
Article in press: March 28, 2020
Published online: May 15, 2020
Core Tip

Core tip: Oxidative stress is involved in obesity, diabetes, and subsequently, diabesity (the co-occurrence of obesity and diabetes). In our study, oxidative stress levels were increased in patients with obesity, diabetes and diabesity. We suggest that the free oxygen radical test and the free oxygen radical defence assays are useful in evaluating the levels of oxidative stress in obesity, diabetes and diabesity. In this study, free oxygen radical test and free oxygen radical defence values also correlated with anthropometric and laboratory parameters in patients with obesity, diabetes and diabesity.