Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2020; 11(4): 90-94
Published online Apr 15, 2020. doi: 10.4239/wjd.v11.i4.90
Published online Apr 15, 2020. doi: 10.4239/wjd.v11.i4.90
Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out?
Paul Ellis Marik, Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, United States
Joseph Varon, Department of Critical Care, United Memorial Medical Service, Houston, TX 77030, United States
Salim R Surani, Texas A and M University, Corpus Christi, TX 78413, United States
Author contributions: All authors have contributed to the preparation of the manuscript, literature search and review of manuscript.
Conflict-of-interest statement: The authors have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Paul Ellis Marik, FRCP (C), MBChB, MD, Chairman, Full Professor, Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, 825 Fairfax Av, Suite 410, Norfolk, VA 23507, United States. marikpe@evms.edu
Received: November 26, 2019
Peer-review started: November 26, 2019
First decision: December 23, 2019
Revised: December 24, 2019
Accepted: February 23, 2020
Article in press: February 23, 2020
Published online: April 15, 2020
Peer-review started: November 26, 2019
First decision: December 23, 2019
Revised: December 24, 2019
Accepted: February 23, 2020
Article in press: February 23, 2020
Published online: April 15, 2020
Core Tip
Core tip: The combination of ascorbic acid (vitamin C), hydrocortisone and thiamine hold great promise for the treatment of sepsis. Despite, significant evidence there remains reluctance among the medical community to adopt this intervention. hydrocortisone, ascorbic acid and thiamine have the potential for saving millions of lives. We await the final jury verdit on this simple, safe and cheap intervention.