Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2020; 11(3): 52-65
Published online Mar 15, 2020. doi: 10.4239/wjd.v11.i3.52
Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats
Temitope Deborah Fabiyi-Edebor
Temitope Deborah Fabiyi-Edebor, Department of Physiology, Afe Babalola University Ado Ekiti, Ado 5454, Ekiti, Nigeria
Author contributions: Fabiyi-Edebor TD designed and performed the research, analysed the data and wrote the paper.
Institutional review board statement: The study was reviewed and approved by Afe Babalola University Institutional Review board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Afe Babalola University with protocol number: [ABUAD-IRB/IACAU/2018/131].
Conflict-of-interest statement: There is no conflict of interest regarding this manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Temitope Deborah Fabiyi-Edebor, PhD, Senior Lecturer, Department of Physiology, Afe Babalola University Ado Ekiti, Kilometres 8.5 Afe Babalola Way, Ado 5454, Ekiti, Nigeria. fabiyitd@abuad.edu.ng
Received: August 6, 2019
Peer-review started: September 8, 2019
First decision: September 21, 2019
Revised: December 7, 2019
Accepted: January 13, 2020
Article in press: January 13, 2020
Published online: March 15, 2020
Core Tip

Core tip: This study reveals that vitamin C maintained normal heart rate variability, blood pressure and sympathetic tone in type 2 diabetic rats. Thus, preventing the symptoms of cardiac autonomic neuropathy. This is done via mechanisms related to downregulation of oxidative stress, inflammation and dyslipidaemia. Vitamin C may therefore possess cardio-autonomic nerve protection potential and may be used to prevent the development of cardiac autonomic neuropathy in type 2 diabetic subjects.