Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2020; 11(10): 435-446
Published online Oct 15, 2020. doi: 10.4239/wjd.v11.i10.435
Comparison of clinical features and outcomes in peritoneal dialysis-associated peritonitis patients with and without diabetes: A multicenter retrospective cohort study
Ling-Fei Meng, Li-Ming Yang, Xue-Yan Zhu, Xiao-Xuan Zhang, Xin-Yang Li, Jing Zhao, Shi-Chen Liu, Xiao-Hua Zhuang, Ping Luo, Wen-Peng Cui
Ling-Fei Meng, Xin-Yang Li, Jing Zhao, Shi-Chen Liu, Xiao-Hua Zhuang, Ping Luo, Wen-Peng Cui, Department of Nephrology, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Li-Ming Yang, Department of Nephrology, The First Hospital of Jilin University-the Eastern Division, Changchun 130041, Jilin Province, China
Xue-Yan Zhu, Department of Nephrology, Jilin Central Hospital, Jilin 132011, Jilin Province, China
Xiao-Xuan Zhang, Department of Nephrology, Jilin FAW General Hospital, Changchun 130041, Jilin Province, China
Author contributions: Meng LF analyzed the data and wrote this manuscript; Li XY, Zhao J, Liu SC, and Zhuang XH collected the data; Yang LM, Zhu XY, and Zhang XX provided the data; Luo P organized the study; Cui WP designed this study and reviewed this manuscript.
Supported by Jilin Province Health and Technology Innovation Development Program Funded Project, No. 2017Q024 and No. 2018FP031.
Institutional review board statement: The study was reviewed and approved by the Second Hospital of Jilin University Institutional Review Board (No. 2020026).
Informed consent statement: Individual informed consent was waived given that the study was retrospective and non-interventional by design.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: The original dataset available from the corresponding author at wenpengcui@163.com. Consent was not obtained but the presented data are anonymized and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wen-Peng Cui, MD, PhD, Doctor, Professor, Department of Nephrology, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, Jilin Province, China. wenpengcui@163.com
Received: June 27, 2020
Peer-review started: June 27, 2020
First decision: July 30, 2020
Revised: August 9, 2020
Accepted: September 8, 2020
Article in press: September 8, 2020
Published online: October 15, 2020
Core Tip

Core Tip: We for the first time confirmed that the symptoms of peritoneal dialysis-associated peritonitis in the diabetes mellitus group were the same as those in the non-diabetes mellitus group. This is the first multicenter retrospective cohort study to examine the relationship between diabetes mellitus and long-term outcome in peritoneal dialysis-associated peritonitis patients. It is also the first study to analyze the profile of distribution of pathogenic organisms and response of peritoneal dialysis-associated peritonitis to medical management in the subset of end-stage renal disease patients with diabetes mellitus. We found that diabetes mellitus was inclined to infection with coagulase-negative Staphylococcus but not Escherichia coli. Diabetes mellitus was associated with higher all-cause mortality but not with adverse therapeutic outcome of peritoneal dialysis-associated peritonitis.