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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2019; 10(6): 333-340
Published online Jun 15, 2019. doi: 10.4239/wjd.v10.i6.333
Published online Jun 15, 2019. doi: 10.4239/wjd.v10.i6.333
Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring
Sofia Nahavandi, The Royal Children’s Hospital Melbourne, Parkville, VIC 3052, Australia
Sarah Price, Priya Sumithran, Elif Ilhan Ekinci, Department of Endocrinology, Austin Health, Repatriation Campus Heidelberg West, Melbourne, VIC 3081, Australia
Sarah Price, Priya Sumithran, Elif Ilhan Ekinci, Department of Medicine, Austin Health and the University of Melbourne (Austin Campus), Parkville, Melbourne, VIC 3084, Australia
Author contributions: Nahavandi S was the primary author. Price S, Sumithran P, and Ekinci EI provided subject matter expertise and edited the manuscript.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Elif Ilhan Ekinci, FRACP, MBBS, PhD, Associate Professor, Sir Edward Dunlop Medical Research Foundation Principal Research Fellow in Metabolic Medicine, Department of Medicine, Austin Health and the University of Melbourne (Austin Campus), Level 1, Centaur Wing, Heidelberg Repatriation Hospital, 300 Waterdale Road, Melbourne, VIC 3084, Australia. elif.ekinci@unimelb.edu.au
Telephone: +61-03-94962250 Fax: +61-03-94974554
Received: March 30, 2019
Peer-review started: April 3, 2019
First decision: May 8, 2019
Revised: May 13, 2019
Accepted: May 23, 2019
Article in press: May 23, 2019
Published online: June 15, 2019
Peer-review started: April 3, 2019
First decision: May 8, 2019
Revised: May 13, 2019
Accepted: May 23, 2019
Article in press: May 23, 2019
Published online: June 15, 2019
Core Tip
Core tip: The prevalence of gestational diabetes is on the rise, warranting attention on the consequences for mother and offspring, as well as management options. One consequence is an increased risk of large for gestational age (LGA) offspring. While deranged macronutrient metabolism of carbohydrate and lipids in gestational diabetes may play a role in fetal overgrowth, there is a lack of conclusive evidence that dietary interventions employed as first-line gestational diabetes management reduces this risk of LGA offspring.