Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2023; 14(10): 1551-1561
Published online Oct 15, 2023. doi: 10.4239/wjd.v14.i10.1551
Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes
Yan-Yan Li, Lin-Ping Tong, Xian-Dan Wu, Dan Lin, Yue Lin, Xiao-Yang Lin
Yan-Yan Li, Lin-Ping Tong, Xian-Dan Wu, Yue Lin, Department of General Practice, The First People’s Hospital of Wenling City, Wenling 317500, Zhejiang Province, China
Dan Lin, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Xiao-Yang Lin, Department of General Medicine, The First People’s Hospital of Wenling City, Wenling 317500, Zhejiang Province, China
Author contributions: Li YY designed and performed the research and wrote the paper; Lin XY designed the research and supervised the report; Tong LP, Wu XD, Lin D, and Lin Y provided clinical advice.
Supported by Wenling Science and Technology Plan Project, No. 2019S0180066.
Institutional review board statement: The study was reviewed and approved by The First People’s Hospital of Wenling City (Approval No. KY-2019-1024-01).
Informed consent statement: All patients signed informed consent forms.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The statistical data in this study can be obtained from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Yang Lin, MM, Associate Chief Physician, Department of General Medicine, The First People’s Hospital of Wenling City, No. 333 Chuanan Road, Chengxi Street, Wenling 317500, Zhejiang Province, China. xiaoyanglin001@163.com
Received: August 1, 2023
Peer-review started: August 1, 2023
First decision: August 16, 2023
Revised: August 22, 2023
Accepted: September 6, 2023
Article in press: September 6, 2023
Published online: October 15, 2023
ARTICLE HIGHLIGHTS
Research background

The high incidence of diabetes mellitus (DM) is a serious threat to public health. There have been many reports on its influencing factors, but few studies on the influence of body weight on the progression from prediabetes to type 2 diabetes mellitus (T2DM), and the interaction between body weight and various influencing factors has not been reported.

Research motivation

The phenomenon of high weight, waist circumference, and body mass index is common in prediabetes patients, and there are many factors affecting the progression of prediabetes to T2DM. Unilateral weight control cannot reduce this risk, and it is necessary to understand the interaction between weight and other factors.

Research objectives

The purpose of this study was to explore the weight status of patients with prediabetes and analyze the interaction between weight and other disease outcome (DO) factors, so as to guide clinical intervention and reduce the risk of prediabetes progressing to T2DM.

Research methods

A retrospective analysis of 236 patients with prediabetes and 50 patients with normal glucose control was performed. Clinical data and follow-up results of all patients were collected. The influencing factors (including body weight) of prediabetes DO were analyzed by logistic regression, and the interaction between body weight and independent influencing factors was analyzed by a general linear model (univariate).

Research results

Body weight, glycosylated hemoglobin, uric acid, fasting insulin (FINS), and homeostatic model assessment for insulin resistance (HOMA-IR) were independent factors affecting the progression of prediabetes to T2DM (P < 0.05). There was a multiplicative interaction between weight and uric acid (β = 1.953, P = 0.005).

Research conclusions

Body weight has a significant effect on prediabetes progression to T2DM, and coexistent high body weight and high uric acid increase the risk of progression to T2DM.

Research perspectives

From the perspective of high body weight as a risk factor for prediabetes progression to T2DM, the interaction between body weight and other risk factors (including glycosylated hemoglobin, uric acid, FINS and HOMA-IR) was discussed, and low carbon diet and weight loss were proposed to reduce the risk of progression and guide clinical intervention.