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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese
Ke-Yu Zhao, Meng-Lu Yuan, Yun-Na Wu, Hong-Wei Cui, Wen-Yan Han, Jing Wang, Xiu-Lan Su
Ke-Yu Zhao, Xiu-Lan Su, Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
Meng-Lu Yuan, School of Public Health, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Yun-Na Wu, Medical Clinical Laboratory, Huhhot First Hospital, Huhhot 010050, Inner Mongolia Autonomous Region, China
Hong-Wei Cui, Department of Scientific Research, Inner Mongolia Autonomous Region Cancer Hospital/The Affiliated People’s Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Wen-Yan Han, Clinical Medical Laboratory Center, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Jing Wang, Graduate School, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Author contributions: Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J and Su XL designed the research study; Zhao KY, Wang J, Yuan ML and Su XL performed the research; Su XL and Zhao KY contributed new reagents and analytic tools; Zhao KY, Yuan ML and Su XL analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81260058.
Institutional review board statement: The study was reviewed and approved by the Affiliated Hospital of Inner Mongolia Medical University Institutional Review Board, No. 2015003.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiu-Lan Su, MMed, Professor, Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, No. 1 North Tongdao Road, Hohhot, 010050, Inner Mongolia Autonomous Region, China. xlsu@sina.com
Received: February 17, 2022
Peer-review started: February 17, 2022
First decision: May 30, 2022
Revised: June 14, 2022
Accepted: July 26, 2022
Article in press: July 26, 2022
Published online: August 15, 2022
ARTICLE HIGHLIGHTS
Research background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are each considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. rs1137101 is a potential risk factor for the occurrence of HTN and T2DM but the association between rs1137101 and HTN + T2DM in the Mongolian and Han population in Inner Mongolia remains unknown.
Research motivation
The association between rs1137101 and occurrence of HTN + T2DM has not been fully elucidated for Mongolian and Han populations in the Inner Mongolia region.
Research objectives
To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia. To illuminate the association between the rs1137101 polymorphism and HTN with T2DM by analyzing differences between Han and Mongolian Chinese.
Research methods
Data relating to blood samples, blood pressure, weight, height and other body indices among Chinese populations in Inner Mongolia. The rs1137101 polymorphism was measured. Data was analyzed by SPSS 22.0 and SNPstats software (https://www.snpstats.net/start.htm) to correlate rs1137101 with HTN + T2DM in Mongolian and Han populations in Inner Mongolia.
Research results
The association between the rs1137101 polymorphism and HTN with T2DM was analyzed, and differences between Han and Mongolian individuals were assessed. There was a significant correlation between rs1137101 with both HTN after adjustment for sex and age in individuals of Mongolian origin. rs1137101 was significantly associated with HTN and HTN + T2DM in the Han Chinese population.
Research conclusions
There was significant correlation between rs1137101 and control and HTN/HTN + T2DM in Han and Mongolian subjects. Mongolian and Han subjects with HTN who had rs1137101 were protected against the development of T2DM. rs1137101 decreased the risk of HTN and HTN + T2DM for the Han Chinese population of Inner Mongolia. By contrast, rs1137101 increased the risk of HTN for the Mongolian population.
Research perspectives
The current study analyzed the association between rs1137101 and HTN/HTN + T2DM by comparing control, HTN and HTN + T2DM groups and found rs1137101 to be associated with HTN and HTN + T2DM in Mongolian and Han populations in Inner Mongolia. Further investigations involving larger study populations with further data relating to environmental and lifestyle factors are required to substantiate interactions between genetics and the environment.
