Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.613
Peer-review started: December 15, 2021
First decision: January 12, 2022
Revised: January 24, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 15, 2022
Apart from Glucagon-like peptide-1 (GLP1) receptor agonists that are being widely used and studied, more effort should also be channeled to designing carrier with sustained release properties for native GLP1 because both approaches may be equally effective in improving the systemic half-life of GLP1.
The GLP1-carbonate apatite nanoparticles (CA NPs) overcome the short half-life of GLP1. The nanoparticles could be a potential therapeutic option for metabolic syndrome and warrant further investigation.
A stable GLP1-CA NPs was successfully fabricated. The NPs improved the systemic half-life of GLP1 as compared with free GLP1-treated rats. The increased plasma GLP1 Level was maintained for at least 4 h post-treatment.
The nanoparticles were fabricated through complexation between GLP1 and CA NPs. The GLP1-CA NPs was then evaluated for physicochemical properties, tested for their potential cytotoxic effects on human cell line, and finally measured for systemic bioavailability in rats through intravenous administration.
To fabricate GLP1-loaded carbonate apatite nanoparticles (GLP1-CA NPs), and improve the systemic half-life of GLP1 through GLP1-CA NPs.
pH sensitive inorganic carbonate apatite nanoparticles, which we have successfully formulated previously may be a potential carrier for GLP1.
GLP1 is an endogenous peptide with established glucose lowering property. Its therapeutic use however is limited due to it being rapidly degraded in the systemic circulation. Nanosize particles with sustained release property may protect as well as extend the plasma half-life of GLP1.