Published online Jan 15, 2021. doi: 10.4239/wjd.v12.i1.56
Peer-review started: September 9, 2020
First decision: October 21, 2020
Revised: November 3, 2020
Accepted: November 18, 2020
Article in press: November 18, 2020
Published online: January 15, 2021
Type 1 diabetes (T1D) contributes to altered lipid profiles and increased cardi-ovascular disease (CVD) risk.
Co-occurrence of T1D and CVD risk factor clustering (overweight/obesity, hypertension, family history of CVD and dyslipidemia) may contribute to early-onset CVD.
We examined the association between CVD risk factors in childhood and dyslipidemia in young adulthood and determined the prevalence of CVD risk factor clustering among T1D patients.
Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D followed in a single tertiary diabetes center for a median duration of 15 years.
Our findings demonstrate that most T1D patients already had at least one CVD risk factor during childhood, with dyslipidemia being the most prevalent. It is noteworthy that clustering of CVD risk factors was observed in approximately one-half of the cohort and that there was a positive family history of at least one CVD risk factor in many patients. The number and distribution of CVD risk factors were similar for males and females.
Our findings suggest that an elevated lipid profile is associated with diastolic blood pressure and positive family history of CVD.
It is of utmost importance to prevent and control modifiable risk factors as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk for dyslipidemia.