Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2017; 8(7): 337-345
Published online Jul 15, 2017. doi: 10.4239/wjd.v8.i7.337
Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Isaac Gbadura Adanlawo
Olusola Olalekan Elekofehinti, Department of Biochemistry, University of Ado-Ekiti, Ado-Ekiti 360221, Ekiti State, Nigeria
Oluwamodupe Cecilia Ejelonu, Oluwaseun Benedicta Akinlosotu, Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko 342111, Ondo State, Nigeria
Jean Paul Kamdem, Departamento de Ciências Biológicas, Universidade Regional do Cariri - URCA, Campus Pimenta, Crato, Ceará 63100-000, Brazil
Isaac Gbadura Adanlawo, Department of Biochemistry, Federal University of Technology, Akure 340252, Ondo State, Nigeria
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest with respect to the research, authorship, and/or publication of this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Olusola Olalekan Elekofehinti, Department of Biochemistry, University of Ado-Ekiti, University Avenue, Akure Ilesha-Akure Expressway, PMB 704, Akure 340252, Ondo State, Nigeria.
Telephone: +234-803-4450611
Received: January 7, 2017
Peer-review started: January 11, 2017
First decision: February 17, 2017
Revised: March 13, 2017
Accepted: April 6, 2017
Article in press: April 10, 2017
Published online: July 15, 2017

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.

Keywords: Adipokines, Adipose tissue, Insulin resistance, Antidiabetic, Obesity

Core tip: β-cell dysfunction and insulin resistance are linked to type 2 diabetes. Adipokines produced from adipose tissues regulate glucose homeostasis and insulin sensitivity. Dysregulation of adipokines are linked to insulin resistance and disruption of glucose Homeostasis. Saponins modulate the activity of some adipokines hence may serve as therapy for treatment of type 2 diabetes.