Yosaee S, Akbari Fakhrabadi M, Shidfar F. Positive evidence for vitamin A role in prevention of type 1 diabetes. World J Diabetes 2016; 7(9): 177-188 [PMID: 27162582 DOI: 10.4239/wjd.v7.i9.177]
Corresponding Author of This Article
Farzad Shidfar, PhD, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Shahid Hemmat Expressway, P.O. Box, Tehran 14665-1579, Iran. shidfar.f@iums.ac.ir
Research Domain of This Article
Immunology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Somaye Yosaee, Maryam Akbari Fakhrabadi, Farzad Shidfar, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran 14665-1579, Iran
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Farzad Shidfar, PhD, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Shahid Hemmat Expressway, P.O. Box, Tehran 14665-1579, Iran. shidfar.f@iums.ac.ir
Telephone: +98-21-88622755 Fax: +98-21-88622533
Received: July 29, 2015 Peer-review started: July 30, 2015 First decision: September 16, 2015 Revised: March 23, 2016 Accepted: April 7, 2016 Article in press: April 11, 2016 Published online: May 10, 2016
Abstract
Type 1 diabetes mellitus (T1DM) as one of the most well-known autoimmune disease, results from the destruction of β-cells in pancreas by autoimmune process. T1DM is fatal without insulin treatment. The expansion of alternative treatment to insulin is a dream to be fulfilled. Currently autoimmunity is considered as main factor in development of T1DM. So manipulation of the immune system can be considered as alternative treatment to insulin. For the past decades, vitamin A has been implicated as an essential dietary micronutrient in regulator of immune function. Despite major advantage in the knowledge of vitamin A biology, patients who present T1DM are at risk for deficiency in vitamin A and carotenoids. Applying such evidences, vitamin A treatment may be the key approach in preventing T1DM.
Core tip: Diet modification and vitamin supplementation is a practical treatment approach for autoimmune diseases. However few broadly studies have been conducted on the use of vitamin A in the treatment of type 1 diabetes. Our objective is to consolidate the current literature to better delineate the vitamin A on immune pathway involved in formation of type 1 diabetes.
