Observational Study
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World J Diabetes. Dec 15, 2014; 5(6): 945-950
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.945
Risk factors for cost-related medication non-adherence among older patients with diabetes
James X Zhang, Jhee U Lee, David O Meltzer
James X Zhang, Jhee U Lee, David O Meltzer, Section of Hospital Medicine, Department of Medicine, the University of Chicago, Chicago, IL 60637, United States
David O Meltzer, Department of Economics, the University of Chicago, Chicago, IL 60637, United States
David O Meltzer, Harris School of Public Policy, the University of Chicago, Chicago, IL 60637, United States
Author contributions: All the authors contributed to this work.
Correspondence to: James X Zhang, PhD, MS, Section of Hospital Medicine, Department of Medicine, the University of Chicago, 5841 S. Maryland Ave., MC 5000, Chicago, IL 60637, United States. xzhang1@medicine.bsd.uchicago.edu
Telephone: +1-773-8341631
Received: June 3, 2014
Revised: July 16, 2014
Accepted: September 6, 2014
Published online: December 15, 2014
Abstract

AIM: To assess the risk factors for cost-related medication non-adherence (CRN) among older patients with diabetes in the United States.

METHODS: We used data from the 2010 Health and Retirement Study to assess risk factors for CRN including age, drug insurance coverage, nursing home residence, functional limitations, and frequency of hospitalization. CRN was self-reported. We conducted multivariate regression analysis to assess the effect of each risk factor.

RESULTS: Eight hundred and seventy-five (18%) of 4880 diabetes patients reported CRN. Age less than 65 years, lack of drug insurance coverage, and frequent hospitalization significantly increased risk for CRN. Limitation in both activities of daily living and instrumental activities of daily living were also generally associated with increased risk of CRN. Residence in a nursing home and Medicaid coverage significantly reduced risk.

CONCLUSION: These results suggest that expanding prescription coverage to uninsured, sicker, and community-dwelling individuals is likely to produce the largest decreases in CRN.

Keywords: Cost, Medication, Non-adherence, Risk factors

Core tip: Using a nationally representative date set, this study explores a wide range of risk factors influencing cost-related medication non-adherence (CRN), which receives increasing recognition of importance in diabetes. The authors found that age less than 65, lack of prescription drug insurance coverage, increased numbers of hospitalizations, and greater functional limitations were associated with higher likelihood of CRN among diabetic patients, while nursing home residence decreased risk. Together, these results suggest that expanding prescription coverage to uninsured, sicker, and community-dwelling individuals is likely to produce the largest decreases in CRN.