Juan F Navarro-González, MD, PhD, FASN, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Diabetes. Aug 15, 2014; 5(4): 431-443 Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.431
Inflammation in diabetic kidney disease
Patricia M García-García, María A Getino-Melián, Virginia Domínguez-Pimentel, Juan F Navarro-González
Patricia M García-García, María A Getino-Melián, Virginia Domínguez-Pimentel, Juan F Navarro-Gonzalez, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Juan F Navarro-González, Spanish National Coordinator of GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética) (RedInRen 12/0021/0019, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad), 38010 Santa Cruz de Tenerife, Spain
Author contributions: García-García PM, Getino-Melián MA and Domínguez-Pimentel V reviewed the literature and wrote the first draft of the manuscript; Navarro-González JF conceived the original idea, reviewed the first draft and revised versions, and finalized the manuscript; all authors approved the final version of the manuscript to be published.
Supported by Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III-Fondo de Investigación Sanitaria), No. PI07/0870 and No. PI10/576; Ministerio de Sanidad y Política Social (Dirección General de Terapias Avanzadas y Trasplante), No. TRA-182; Sociedad Española de Nefrología y ACINEF; Research activity by Navarro-González JF is supported by Programa de Intensificación de la Actividad Investigadora, ISCIII/Canarias
Correspondence to: Juan F Navarro-González, MD, PhD, FASN, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Telephone: +34-92-2602061 Fax: +34-92-2602349
Received: October 4, 2013 Revised: February 24, 2014 Accepted: June 10, 2014 Published online: August 15, 2014
Abstract
Diabetes mellitus entails significant health problems worldwide. The pathogenesis of diabetes is multifactorial, resulting from interactions of both genetic and environmental factors that trigger a complex network of pathophysiological events, with metabolic and hemodynamic alterations. In this context, inflammation has emerged as a key pathophysiology mechanism. New pathogenic pathways will provide targets for prevention or future treatments. This review will focus on the implications of inflammation in diabetes mellitus, with special attention to inflammatory cytokines.
Core tip: Diabetic kidney disease is the main cause of renal insufficiency. This complication results from interactions of genetic and environmental factors that trigger a complex network of pathophysiological events. Inflammation has emerged as a key pathophysiology mechanism with important implications from a therapeutic perspective.
