Richard JL, Sotto A, Lavigne JP. New insights in diabetic foot infection. World J Diabetes 2011; 2(2): 24-32 [PMID: 21537457 DOI: 10.4239/wjd.v2.i2.24]
Corresponding Author of This Article
Jean-Philippe Lavigne, MD, PhD, Doctor of Medicine, President of GP30, Laboratory of Bacteriology, Carémeau Hospital, University Hospital of Nîmes, Nîmes 30029, France. jean.philippe.lavigne@chu-nimes.fr
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Guidelines For Clinical Practice
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World J Diabetes. Feb 15, 2011; 2(2): 24-32 Published online Feb 15, 2011. doi: 10.4239/wjd.v2.i2.24
New insights in diabetic foot infection
Jean-Louis Richard, Albert Sotto, Jean-Philippe Lavigne
Jean-Louis Richard, Department of Nutritional Diseases and Diabetology, Medical Centre, University Hospital of Nîmes, Le Grau du Roi 30240, France
Albert Sotto, Department of Infectious Diseases, Carémeau Hospital, University Hospital of Nîmes, 30029 Nîmes and INSERM, ERI 26, UFR de Médecine, 30908 Nîmes Cedex 02, France
Jean-Philippe Lavigne, Laboratory of Bacteriology, Carémeau Hospital, University Hospital of Nîmes, 30029 Nîmes, France and INSERM, ERI 26, UFR de Médecine, 30908 Nîmes Cedex 02, France
Author contributions: Richard JL, Sotto A and Lavigne JP structured the outline of this article; Richard JL and Lavigne JP drafted this manuscript; and all the authors did the final editing.
Supported by Institut National de la Santé Et de la Recherche Médicale, the French Speaking Association for Diabetes and Metabolic Diseases (ALFEDIAM grant) and the University of Montpellier 1, the Languedoc-Roussillon Area (Chercheur d’avenir Grant) and the City of Nîmes
Correspondence to: Jean-Philippe Lavigne, MD, PhD, Doctor of Medicine, President of GP30, Laboratory of Bacteriology, Carémeau Hospital, University Hospital of Nîmes, Nîmes 30029, France. jean.philippe.lavigne@chu-nimes.fr
Telephone: +33-4-66683202 Fax: +33-4-66684254
Received: July 26, 2010 Revised: August 28, 2010 Accepted: September 4, 2010 Published online: February 15, 2011
Abstract
Foot ulcers are common in diabetic patients, have a cumulative lifetime incidence rate as high as 25% and frequently become infected. The spread of infection to soft tissue and bone is a major causal factor for lower-limb amputation. For this reason, early diagnosis and appropriate treatment are essential, including treatment which is both local (of the foot) and systemic (metabolic), and this requires coordination by a multidisciplinary team. Optimal treatment also often involves extensive surgical debridement and management of the wound base, effective antibiotic therapy, consideration for revascularization and correction of metabolic abnormalities such as hyperglycemia. This article focuses on diagnosis and management of diabetic foot infections in the light of recently published data in order to help clinicians in identification, assessment and antibiotic therapy of diabetic foot infections.
