Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2021; 12(6): 827-838
Published online Jun 15, 2021. doi: 10.4239/wjd.v12.i6.827
Diabetes and peripheral artery disease: A review
David Olubukunmi Soyoye, Olugbenga Olusola Abiodun, Rosemary Temidayo Ikem, Babatope Ayodeji Kolawole, Anthony Olubunmi Akintomide
David Olubukunmi Soyoye, Rosemary Temidayo Ikem, Babatope Ayodeji Kolawole, Anthony Olubunmi Akintomide, Department of Medicine, Obafemi Awolowo University, Ile-Ife 220282, Osun State, Nigeria
David Olubukunmi Soyoye, Rosemary Temidayo Ikem, Babatope Ayodeji Kolawole, Anthony Olubunmi Akintomide, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife 220282, Osun State, Nigeria
Olugbenga Olusola Abiodun, Department of Medicine, Federal Medical Centre, Jabi 900211, Abuja, Nigeria
Author contributions: All the authors contributed to the initial writing and subsequent reviews of this manuscript.
Conflict-of-interest statement: The authors have no competing interests to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: David Olubukunmi Soyoye, FMCP, FACE, FACP, MBChB, Consultant Physician-Scientist, Senior Lecturer, Department of Medicine, Obafemi Awolowo University, Ife-Ibadan Expressway, Ile-Ife 220282, Osun State, Nigeria.
Received: February 13, 2021
Peer-review started: February 13, 2021
First decision: March 16, 2021
Revised: April 22, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: June 15, 2021

Peripheral arterial disease (PAD) refers to partial or complete occlusion of the peripheral vessels of the upper and lower limbs. It usually occurs as part of systemic atherosclerosis in the coronary and cerebral arteries. The prevalence of PAD is expected to continue to increase in the foreseeable future owing to the rise in the occurrence of its major risk factors. Nonhealing ulcers, limb amputation and physical disability are some of its major complications. Diabetes mellitus (DM) remains a major risk for PAD, with DM patients having more than two-fold increased prevalence of PAD compared with the general population. The clinical presentation in people with DM also differs slightly from that in the general population. In addition, PAD in DM may lead to diabetic foot ulcers (DFUs), which precipitate hyperglycaemic emergencies and result in increased hospital admissions, reduced quality of life, and mortality. Despite the epidemiological and clinical importance of PAD, it remains largely under diagnosed and hence undertreated, possibly because it is largely asymptomatic. Emphasis has been placed on neuropathy as a cause of DFUs, however PAD is equally important. This review examines the epidemiology, pathophysiology and diagnosis of lower limb PAD in people with diabetes and relates these to the general population. It also highlights recent innovations in the management of PAD.

Keywords: Diabetes, Peripheral arterial disease, Diabetic foot ulcers, Lower limb complications

Core Tip: Peripheral arterial disease (PAD) is a major cause of nonhealing ulcers, lower limb amputation and mortality, especially in people with diabetes. The ominous association between PAD and diabetic foot disease is largely under-reported. Hence, it is under diagnosed and undertreated. This article reviews the impact of PAD in diabetes, its traditional and non-traditional risk factors, and pathophysiology, and examines some recent innovations in its management.