Published online Mar 15, 2021. doi: 10.4239/wjd.v12.i3.278
Peer-review started: November 20, 2020
First decision: December 24, 2020
Revised: December 30, 2020
Accepted: February 11, 2021
Article in press: February 11, 2021
Published online: March 15, 2021
Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown.
To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON.
We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.
ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (r = -0.9336, P < 0.0001 and r =
Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.
Core Tip: Through the analysis of resting state functional magnetic resonance imaging, combined with the statistical calculation of all data, this study aimed to understand altered spontaneous brain activity in patients with diabetic optic neuropathy, and find out the differences of regional homogeneity values in different brain regions as well as the correlation of other clinical related behaviors, so as to guide the diagnosis and prevention of diabetes optic neuropathy.