Where does chemotherapy stands in the treatment of ampullary carcinoma? A review of literature

Table 1 Response rate, time to progression and survival in patients with localized ampullary carcinoma

Ref.	n	Patient characteristics	Protocols	OS	RR/TTP
Lee et al[23]	39	1988-1997 33% CRT	RT (48.7 Gy) with continuous/concurrent infusion of 5-FU	3 yr: 55%	3 yr: 54% DFS
Sikora et al[24]	113	1989-2000 104 patients remained alive after surgery	RT (50.4 Gy) with concurrent 5-FU	OS: 30 mo 1 yr: 79% 3 yr: 43% 5 yr: 33%	NC
Bhatia et al[25]	125	1977-2005	29 patients: RT (50.4 Gy) with 5-FU 96 surgery	3.4 yr 1.6 yr	NC
Krishnan et al[26]	96	1990-2006 56% CRT	RT (45 Gy preop or 50.4 Gy postop) with 5-FU (42%) or capecitabine (43%)	25.2 mo in patients with CRT vs 16.5 mo in control arm	NC
Kim et al[27]	118	1991-2002 35% CRT	RT (40 Gy) with 5-FU (day 1, 3) every split course	5 yr: 52.8% vs 66.9% in the control arm	NC
Narang et al[28]	186	1992-2007	RT with 5-FU	39.9 mo 2 yr: 62.4% 5 yr: 39.1%	NC
Palta et al[29]	137	1976-2009	61 CRT 43 adjuvant 18 neoadjuvant	3 yr: 62% in CRT and 46% in adjuvant	Neoadjuvant: 28% pCR
Jiang et al[30]	64	1992-2009	5-FU-based vs gemcitabine based	5-FU trend toward benefit for OS (P = 0.007)	5-FU significant improvement for TTP

CRT: Chemoradiotherapy; NC: Not calculated; OS: Overall survival; RT: Radiotherapy; TTP: Time to progression.

Table 2 Response rate, time to progression and survival in patients with advanced

Ref.	n	Patient characteristics	Protocols	OS	RR/TTP
Kim et al[32]	29	2003-2008	31% Cis + Gem 69% Cis + 5-FU	12.5 mo (no significant difference between the two groups)	NC
Shoji et al[33]	26	1997-2010	5-FU-based gemcitabine-based 5-FU based gemcitabine-based	OS = 9.1 mo 8 mo 12.3 mo	RR = 7.7%

Cis: Cisplatin; Gem: Gemcitabine; NC: Not calculated; OS: Overall survival; RR: Response rate; TTP: Time to progression.