Original Article
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Jul 15, 2014; 6(7): 225-243
Published online Jul 15, 2014. doi: 10.4251/wjgo.v6.i7.225
Table 1 AIN-93G diet composition
IngredientsPercentage
Corn starch39.75%
Casein vitamin free20%
Maltodextrin13.20%
Sucrose10%
Soybean oil7%
Powdered cellulose5%
AIN 93G mineral mix3.50%
AIN 93 vitamin mix1%
L-cystine0.30%
Choline bitartrate0.25%
t-butylhydroquinone0.0014%
Table 2 Mice fed diet + deoxycholic acid
Mouse weights (g)Locations of tumors
Hyper-plastic polypCharacteristics of polyps low and high grade dysplasia including those from which cancers arose
Stages of cancers found
Distal tumorProximal tumorTubular adenomaSessile serrated adenomaUlcerated adenomaAdenoma with HGDIntra-mucosal ACStage T1 ACStage T2 AC
18.733
243211
2522
25.81111
25.93321
26.11111
26.13322
27.32211
27.45533
28.822
35.4NoneNone
35.72323
38.92222
40321
41.143312
43221
43.1111
45.21111
45.2221
49.2NoneNone
53.773414
78.633
Totals134423715173792
Table 3 Comparison of diet alone to diet + deoxycholic acid on colonic tumor and cancer development n (%)
DietDiet (mo)MiceMice with tumors(adenomas + cancers)Mice with cancerTumors(tumor burden1)Cancers(cancer burden2)
Diet alone1022000 (0)0 (0)
Diet + DOC102220 (91%)10 (45%)57 (2.6)18 (0.82)