Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target

Table 1 Summary of N6-methyladenosine modification of messenger RNAs in colorectal cancer

METTL3 expression	M6A modified mRNAs	Function of METTL3	Ref.
Upregulation	CCN1	Cell proliferation	Zhu et al[61]
Upregulation	YPEL5	Cell proliferation	Zhou et al[62]
Upregulation	PTTG3P	Cell proliferation	Zheng et al[63]
Upregulation	KIF26B	Cell invasion and migration	Chen et al[64]
Downregulation	P38/ERK	Cell invasion and migration	Deng et al[65]
Upregulation	HK2 and GLUT1	Metabolism	Shen et al[45]
Upregulation	GLUT1	Metabolism	Chen et al[66]
Upregulation	REG1α	Metabolism	Zhou et al[67]
Upregulation	P53R273H	Drug resistance	Uddin et al[68]
Upregulation	RAD51AP1	Drug resistance	Li et al[69]
Upregulation	TRAF5	Drug resistance	Lan et al[70]
Upregulation	LDHA	Drug resistance	Zhang et al[71]

ERK: Extracellular regulated protein kinases; HK2: Hexokinase 2; GLUT1: Glucose transporter type 1; mRNAs: Messenger RNAs; m6A: N6-methyladenosine.

Table 2 Summary of N6-methyladenosine modification of noncoding RNAs in colorectal cancer

METTL3 expression	M6A modified ncRNAs	Function of METTL3	Ref.
Upregulation	SNHG1	Cell proliferation	Xu et al[84]
Upregulation	FAM83H-AS1	Cell proliferation	Luo et al[85]
Upregulation	pri-miRNA-1246	Cell invasion and migration	Peng et al[78]
Upregulation	circ1662	Cell invasion and migration	Chen et al[86]
Upregulation	POU6F2-AS1	Metabolism	Jiang et al[87]
Upregulation	miR-181b-5p	Drug resistance	Pan et al[88]
Upregulation	Circ0124554	Drug resistance	Zhong et al[89]

pri-miRNA: Primary miRNA; ncRNAs: Noncoding RNAs; m6A: N6-methyladenosine.