E3 ubiquitin ligase TRIM55 promotes metastasis of gastric cancer cells by mediating epithelial-mesenchymal transition

Table 1 Immunohistochemical expression of TIRM55 in gastric cancer and normal tissues

Tissue	N	High expression	Low expression	P value
Gastric cancer	91	40	51	< 0.001
Normal	91	3	89

Table 2 Association between TRIM55 expression and clinicopathological characteristics

Variables	No. of case	TRIM55 expression		χ2	P value
		High (n = 40)	Low (n = 51)
Gender				0.284	0.594
Male	61	28	33
Female	30	12	18
Age (n)				0.216	0.642
≤ 65	48	20	28
> 65	43	20	23
Tumor location				0.008	0.928
Proximal	14	6	8
Dismatal	77	34	43
pT stage				6.232	0.013
T1 + T2	43	13	30
T3 + T4	48	27	21
Lymph node metastasis				5.506	0.019
Negative	49	16	33
Positive	42	24	18
TNM stage				5.146	0.023
Ⅰ + Ⅱ	53	18	35
Ⅲ	38	22	16
Lauren histotype				3.366	0.067
Intestinal	47	25	22
Diffuse	44	15	29

Table 3 Univariate and multivariate Cox regression models for estimating the overall survival

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender	0.79	0.12–1.38	0.463
Age	0.56	0.38–1.50	0.517
Tumor location	1.67	0.53–2.27	0.770
pT stage	0.85	0.61–0.93	0.041
Lymph node metastasis	3.29	2.07–5.44	0.005	2.64	1.35–3.08	0.021
TNM stage	2.18	1.32–2.89	0.016	1.20	1.06–1.88	0.028
Lauren histotype	1.45	0.39–2.46	0.433
TRIM55	2.37	1.53–3.81	0.028	1.48	1.17–1.92	0.035

HR: Hazard ratio; CI: Confidence interval.