Analysis of factors potentially predicting prognosis of colorectal cancer

Table 1 Comparison of indicators between the good prognosis group and poor prognosis group before treatment

	Good prognosis group (n = 274)	Poor prognosis group (n = 81)	t/χ2 value	P value
Age	53.64 ± 15.38	60.47 ± 8.34	3.831	0.000
Gender (Male/Female)	143/131	43/38	0.020	0.887
BMI (kg/m2)	26.49 ± 5.34	25.39 ± 5.91	1.589	0.113
Smoking [n (%)]	74 (27.01%)	24 (29.63%)	0.215	0.643
History of alcohol abuse [n (%)]	39 (14.23%)	13 (16.05%)	0.165	0.685
Family history [n (%)]	46 (16.79%)	20 (24.69%)	2.580	0.108
Tumor diameter (cm)	2.08 ± 1.47	5.69 ± 2.54	16.125	0.000
Tumor location
Ascending colon [n (%)]	39	13	3.139	0.535
Transverse colon [n (%)]	14	7
Lower colon [n (%)]	25	10
Sigmoid colon [n (%)]	84	22
Rectum [n (%)]	112	29
Tumor histology type
Adenocarcinoma	177	53	0.019	0.890
Mucinous adenocarcinoma and signet ring cell carcinoma	97	28
TNM stage
I	10 (3.65%)	6 (7.41%)	29.292	0.000
II	213 (77.74%)	38 (46.91%)
III	30 (10.95%)	24 (29.63%)
IV	21 (7.66%)	13 (16.05%)
Dukes stage
A	17 (6.20%)	1 (1.23%)		0.062
B	177 (64.60%)	48 (59.26%)
C	80 (29.20%)	32 (39.51%)
PCNA
1	98	4	114.291	0.000
2	122	11
3	45	43
4	9	23
P53
-	34	11	4.908	0.297
+	64	14
++	61	17
+++	78	23
++++	37	19
GPS
0	233 (85.04%)	9 (11.11%)	157.579	0.000
1	24 (8.76%)	40 (49.38%)
2	17 (6.20%)	32 (39.51%)
C-reactive protein (mg/L)	2.73 ± 0.64	21.83 ± 16.34	19.364	0.000
Albumin (g/L)	42.43 ± 7.93	33.74 ± 6.21	9.071	0.000
WBC count (9 × 103/mm3)	5.89 ± 1.98	8.53 ± 2.83	9.481	0.000
Platelet count (9 × 104/mm3)	237.43 ± 103.28	247.23 ± 116.39	0.728	0.467
NLR	2.68 ± 1.73	4.53 ± 3.29	6.699	0.000
CAR	0.089 ± 0.017	0.175 ± 0.092	14.693	0.000
D-dimer (μg/mL)	0.553 ± 0.207	0.943 ± 0.375	13.117	0.000
Fibrinogen (g/L)	3.121 ± 1.542	3.524 ± 1.053	2.204	0.028
CEA (ng/mL)	3.34 ± 1.82	6.13 ± 2.36	11.281	0.000
CA199 (U/mL)	186.82 ± 139.74	635.24 ± 284.38	15.067	0.000

BMI: Body mass index; TNM: Tumor-node-metastasis; PCNA: Proliferating cell nuclear antigen; GPS: Glasgow prognostic score; WBC: White blood cell; NLR: Neutrophil-lymphocyte ratio; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199.

Table 2 COX regression analysis of influence factors on the prognosis of colorectal cancer

	B	SE	Wald	P value	RR	95%CI
						Lower limit	Upper limit
Age	0.241	0.223	1.328	0.154	1.273	0.822	1.971
Tumor diameter	0.160	0.315	1.142	0.328	1.173	0.633	2.175
TNM Stage	1.762	0.442	7.364	0.000	5.824	2.449	13.850
PCNA	1.534	0.382	6.338	0.000	4.635	2.192	9.800
GPS	2.238	0.448	8.927	0.000	9.377	3.897	22.564
C-reactive protein	0.454	0.355	2.773	0.058	1.574	0.785	3.156
Albumin	-0.129	0.371	2.538	0.105	0.879	0.425	1.819
WBC count	0.149	0.433	1.292	0.183	1.161	0.497	2.713
NLR	0.816	0.233	6.792	0.000	2.261	1.432	3.570
CAR	2.678	0.341	9.338	0.000	14.552	7.459	28.391
D-dimer	2.498	0.636	8.923	0.000	12.153	3.494	42.272
Fibrinogen	0.603	0.386	0.751	0.625	1.827	0.857	3.893
CEA	1.342	0.492	6.877	0.000	3.827	1.459	10.038
CA199	0.226	0.553	1.149	0.322	1.253	0.424	3.704

TNM: Tumor-node-metastasis; PCNA: Proliferating cell nuclear antigen; GPS: Glasgow prognostic score; WBC: White blood cell; NLR: Neutrophil-lymphocyte ratio; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199.

Table 3 Receiver-operating characteristic (ROC) curve analysis of potential indicators for predicting the prognosis of colorectal cancer

	AUC	95%CI	Best diagnostic point	Sensitivity (%)	Specificity (%)
TNM Stage	0.613	0.560-0.663	2	45.68	81.39
PCNA	0.837	0.794-0.874	2	81.48	80.29
GPS	0.872	0.832-0.905	1	88.89	85.04
NLR	0.925	0.860-0.966	0.206	94.12	80.25
CAR	0.743	0.695-0.788	4.81	45.68	94.53
D-dimer	0.879	0.841-0.911	0.795 (μg/mL)	58.02	100
CEA	0.801	0.755-0.841	3.891 (ng/mL)	76.54	64.60

TNM: Tumor-node-metastasis; PCNA: Proliferating cell nuclear antigen; GPS: Glasgow prognostic score; NLR: Neutrophil-lymphocyte ratio; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen.