Hypermethylation of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia

Table 1 Methylation frequencies of tumor suppressor and tumor-related genes in non-neoplastic gastric epithelia from younger and eldery individuals

	< 32 years of age			> 44 years of age
	U (n = 7)	M (n = 11)	L (n = 7)	U (n = 23)	M (n = 25)	L (n = 22)
APC	57	36	57	91	96	95
E-cadherin	0	0	0	78	76	64
DAP-kinase	0	0	0	78	80	68
p16	0	0	0	30	16	18
RUNX3	0	0	0	4	4	32
RASSF1A	0	0	0	4	12	5
hMLH1	0	0	0	4	0	14
GSTP1	0	0	0	0	0	0

U: Upper third portion; M: Middle third portion; L: Lower third portion.