Clinical efficacy and safety of second line and salvage aflibercept for advanced colorectal cancer in Akita prefecture
Taichi Yoshida, Daiki Taguchi, Kazuhiro Shimazu, Koji Fukuda, Hiroyuki Shibata, Department ofClinical Oncology, Akita University Graduate School of Medicine, Akita 010-8543, Japan
Kentaro Takahashi, Department ofGastroenterological Surgery, Nakadori General Hospital, Akita 010-8577, Japan
Kengo Shibuya, Department ofGastroenterology, Akita Kousei Medical, Akita 010-0948, Japan
Osamu Muto, Yuko Yoshida, Department ofMedical Oncology, Akita Red Cross Hospital, Akita 010-1495, Japan
Fuminori Ono, Department ofSurgery, Omagari Kousei Medical Center, Akita 014-0027, Japan
Kyoko Nomura, Department ofEnvironmental Health Science and Public Health, Akita University Graduate School of Medicine, Akita 010-8543, Japan
Author contributions: Yoshida T drafted the article; all authors contributed to development of the study protocol, data collection, and analysis, and revision of the manuscript for important intellectual content.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki. The protocol was approved by the Institutional Review Board at Akita University, November 2018 (#2070).
Informed consent statement: Informed consent was not obtained from all participants, as it was not required due to the retrospective and observational nature of the study design.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional date is available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroyuki Shibata, MD, PhD, Professor, Department of Clinical Oncology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan. email@example.com
Received: December 28, 2020
Peer-review started: December 28, 2020
First decision: January 17, 2021
Revised: January 28, 2021
Accepted: March 11, 2021
Article in press: March 11, 2021
Published online: April 15, 2021