ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma

Figure 3 Diagnostic accuracy of the VWF:Ag/ADAMTS13:AC for sorafenib response. The receiver operating characteristic analysis of the VWF:Ag/ADAMTS13:AC ratio for sorafenib response reveals that a cutoff VWF:Ag/ADAMTS13:AC ratio of 2.609 has a specificity of 84.2% and a sensitivity of 88.2%, with an area under the receiver operating characteristic curve of 0.836. ADAMTS13: A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13; ADAMTS13:AC: ADAMTS13 activity; VWF: Von Willebrand factor; VWF:Ag: VWF antigen; VWF:Ag/ADAMTS13:AC ratio: The ratio of VWF:Ag to ADAMTS13:AC.