ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma
Hiroaki Takaya, Tadashi Namisaki, Naotaka Shimozato, Kosuke Kaji, Mitsuteru Kitade, Kei Moriya, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Hitoshi Yoshiji, Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan
Masanori Matsumoto, Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan
Author contributions: Takaya H, Shimozato N, Kaji K, Kitade M, Moriya K, Sato S, Kawaratani H, Akahane T and Matsumoto M performed data analysis; Takaya H, Namisaki T and Yoshiji H contributed to the writing of the manuscript.
Institutional review board statement: Informed consent for the use of resected tissue was obtained from all patients and the study protocol was approved by the Ethics Committee of Nara Medical University.
Informed consent statement: All study participants or their legal guardians provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hiroaki Takaya, MD, PhD, Assistant Professor, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan. firstname.lastname@example.org
Telephone: +81-744-223051 Fax: +81-744-247122
Received: January 30, 2019
Peer-review started: February 14, 2019
First decision: March 14, 2019
Revised: March 26, 2019
Accepted: April 8, 2019
Article in press: April 8, 2019
Published online: May 15, 2019