Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer

Figure 1 Flow diagram. CRC: Colorectal cancer; CT: Computed tomography.

Figure 2 Class changes in body composition during treatment. Percentage changes in the prevalence of abnormal body composition from baseline to after the last systemic chemotherapy were shown. S: Sarcopenia; ScO: Subcutaneous obesity; M: Myosteatosis; mo: Months; VO: Visceral obesity.

Figure 3 Restricted cubic spline curve showing the hazard ratios of body composition parameters and survival. A: Sarcopenia T score; B: Myosteatosis T score; C: Visceral fat area; D: Subcutaneous fat area index; E: Body mass index. P values are for nonlinearity.

Figure 4 Baseline status and changes in body composition and their association with survival after the last systemic chemotherapy. A: Sarcopenia; B: Myosteatosis; C: Visceral obesity; D: Subcutaneous obesity. Decrease in the sarcopenia and myosteatosis indices, visceral fat, and subcutaneous fat were defined as sarcopenia T-scores < -0.5, myosteatosis T-scores < -0.5, visceral fat area < -20%, subcutaneous fat area index < -15%, respectively. ScO: Subcutaneous obesity; mo: Months; VO: Visceral obesity; HR: Hazard ratio.

Figure 5 Correlation matrix at baseline, after the last systemic chemotherapy. A: Correlation matrix at baseline; B: After the last systemic chemotherapy. The numbers shown are Pearson’s correlation coefficients with P values < 0.05. Negative and positive values indicate negative and positive correlations, respectively. Blanks indicate nonsignificant values. Alb: Albumin; ALC: Absolute lymphocyte count; BMI: Body mass index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SFAI: Subcutaneous fat area index; T-chol: Total cholesterol; VFA: Visceral fat area.