Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer

doi:10.4251/wjgo.v17.i5.103479

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Oncol. May 15, 2025; 17(5): 103479
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.103479

Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer

Hyehyun Jeong, Yousun Ko, Kyung Won Kim, Ji Sung Lee, Seyoung Seo, Sun Young Kim, Yong Sang Hong, Jeong Eun Kim, Tae Won Kim

Hyehyun Jeong, Seyoung Seo, Sun Young Kim, Yong Sang Hong, Jeong Eun Kim, Tae Won Kim, Department of Oncology, Asan Medical Center, Seoul 05505, South Korea

Yousun Ko, Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, South Korea

Kyung Won Kim, Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea

Ji Sung Lee, Clinical Research Center, Asan Medical Center, Asan Medical Center, Seoul 05505, South Korea

Co-corresponding authors: Jeong Eun Kim and Tae Won Kim.

Author contributions: Jeong H performed formal analysis, conducted investigations, prepared the initial draft of the manuscript, and created visualizations for the study; Ko Y and Kim KW developed the software used in this study and analyzed imaging data; Lee JS performed formal analysis; Seo S, Kim SY, and Hong YS curated data; Kim SY, Kim JE and Kim TW obtained the funds for the research project; All authors reviewed and edited the manuscript. Kim JE and Kim TW proposed, conceptualized, and supervised the study, interpreted the data, and managed project administration.

Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, by the Ministry of Health & Welfare, Republic of Korea, No. RS-2018-KH049509; and the 2022 Cancer Research Support Project from the Korea Foundation for Cancer Research, No. CB-2022-A-3.

Institutional review board statement: This study was approved by the institutional review board of Asan Medical Center and performed in accordance with the ethical standards of the institutional research committee and the Declaration of Helsinki (IRB No. 2021-0078).

Informed consent statement: The requirement for informed consent was waived by the IRB for this retrospective study.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request at jeongeunkim@amc.seoul.kr.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jeong Eun Kim, MD, PhD, Department of Oncology, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. jeongeunkim@amc.seoul.kr

Received: November 21, 2024
Revised: February 22, 2025
Accepted: April 15, 2025
Published online: May 15, 2025
Processing time: 175 Days and 22.5 Hours

Core Tip

Core Tip: This retrospective study included a homogeneous group of patients with metastatic colorectal cancer undergoing palliative chemotherapy, monitoring body composition changes through serial computed tomography scans during treatment. The majority of patients experienced changes in body composition, with an increased prevalence of sarcopenia and myosteatosis, both linked to poor survival outcomes. In contrast, visceral and subcutaneous obesity were associated with improved survival. Furthermore, changes in body composition during systemic therapy correlated with end-of-life survival. These findings suggest the prognostic value of monitoring body composition through routine computed tomography scans during chemotherapy.