Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression

doi:10.4251/wjgo.v13.i9.980

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Sep 15, 2021 (publication date) through Apr 25, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2021; 13(9): 980-994
Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.980

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Figure 1 Schematic illustration of Tenascin-C and the amino acid sequence of peptide TNIIIA2. Conformational change in integrin activation via the lateral interaction of integrin with syndecan-4 at peptide TNIIIA2. Created with BioRender.com.

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Figure 2 Schematic model of the effect of TNIIIA2 on the metastasis of colon cancer cells. Peptide TNIIIA2 boosts the infiltration of colon cancer cells via matrix metalloproteinases production in vitro and promotes pulmonary metastasis in a spontaneous metastasis mouse model. Created with BioRender.com. MMP: Matrix metalloproteinases.

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Figure 3 Schematic model of the effect of TNIIIA2 on colitis-associated colorectal cancer onset. Peptide TNIIIA2 stimulates fibroblasts to secrete humoral factors, promoting anchorage-dependent and -independent growth in preneoplastic cells. Created with BioRender.com. CAC: Colitis-associated colorectal cancer.

Citation: Fujita M, Suzuki H, Fukai F. Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression. World J Gastrointest Oncol 2021; 13(9): 980-994
URL: https://www.wjgnet.com/1948-5204/full/v13/i9/980.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i9.980