Achievement of complete response to nivolumab in a patient with advanced sarcomatoid hepatocellular carcinoma: A case report

Figure 1 Magnetic resonance imaging and histology. A: MRI showing the location of the tumor in the liver segments 4/8; B: Histology of the tumor tissue (40 ×). The tumor displayed fish-like changes throughout, with atypical cells and lymphocyte infiltration observed.

Figure 2 Computed tomography scans before and after immunotherapy. A-C: Computed tomography scan showing metastasis of the mediastinal lymph nodes, recurrent hepatic lesions that led to compression of the bile duct, and a new metastatic lesion in the abdominal cavity; D-F: Metastatic lesions showing achievement of complete response2 mo after receiving nivolumab. In addition, compression of the bile duct was relieved.

Figure 3 Immunohistochemical staining for programmed death-ligand 1 (40 ×). A: Positive control (Ab 28-8); B: Tumor (Ab 28-8).

Figure 4 Computed tomography scans before and after corticosteroid treatment for interstitial pneumonia. A: Computed tomography (CT) scan showing bilateral interstitial pneumonia caused by the PD-1 inhibitor; B: CT scan showing that pneumonia was alleviated by corticosteroid treatment.