Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients
Gilmar Ferreira do Espírito Santo, Gabriela Tognini Saba, Jaques Waisberg, Department of Surgery - Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04024-002, Brazil
Bianca Borsatto Galera, Lenuce Azis, Amilcar Sabino Damazo, Genetic Laboratory Basics Health Sciences Department, Medical School of Federal University of Mato Grosso, Cuiabá 78060-900, Brazil
Elisabeth Carmen Duarte, Tropical Medicine Division, Medical School of Brasilia University, Campus Darcy Ribeiro University, Brasília 70904-970, Brazil
Elisabeth Suchi Chen, Laboratory of Genetics of Morphology and Genetics Department, Federal University of São Paulo, São Paulo 04023-900, Brazil
Flávia de Sousa Gehrke, Laboratory of Clinical Analysis, ABC Medical School, avenida Príncipe de Gales, Santo André 09060-650, Brazil
Ismael Dale Cotrim Guerreiro da Silva, Laboratory of Molecular Gynecology, Department of Gynecology, Federal University of São Paulo, rua Pedro de Toledo, São Paulo 04039-032, Brazil
Author contributions: do Espírito Santo GF, Galera BB and Waisberg J participated in the design of the study, statistical analysis and the manuscript preparation; Chen ES, Azis L and Damazo AS participated in the sample collection and analyzed the data from the real-time PCR assays; Duarte EC performed the statistical analyses; do Espírito Santo GF, Galera BB, Saba GT, de Sousa Gehrke F and Guerreiro da Silva IDC participated in the manuscript preparation; all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Research Ethic Committee of UNIC (University of Cuiabá) and in the Research Ethic Committee of Federal University of São Paulo.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jaques Waisberg, MD, PhD, FACS, Department of Surgery - Escola Paulista de Medicina, Federal University of São Paulo, Rua Napoleão de Barros, 715, Vila Clementino, São Paulo 04024-002, Brazil. firstname.lastname@example.org
Telephone: +55-11-982560018 Fax: +55-11-44368739
Received: June 24, 2016
Peer-review started: June 24, 2016
First decision: August 18, 2016
Revised: September 18, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: February 15, 2017