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World J Gastrointest Oncol. Mar 15, 2016; 8(3): 282-288
Published online Mar 15, 2016. doi: 10.4251/wjgo.v8.i3.282
Emerging role of cystic fibrosis transmembrane conductance regulator - an epithelial chloride channel in gastrointestinal cancers
Yuning Hou, Xiaoqing Guan, Zhe Yang, Chunying Li
Yuning Hou, Xiaoqing Guan, Zhe Yang, Chunying Li, Department of Biochemistry and Molecular Biology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, United States
Author contributions: Hou Y reviewed and analyzed the literature and wrote the manuscript; Guan X and Yang Z reviewed the manuscript; Li C reviewed and revised the manuscript and gave the final approval of the manuscript.
Supported by American Cancer Society Institutional Research to Li C, No. 11-053-01-IRG; and National Institutes of Health grant HL128647 to Li C.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chunying Li, PhD, Department of Biochemistry and Molecular Biology, Karmanos Cancer Institute, Wayne State University School of Medicine, 540 E. Canfield Avenue, 5312 Scott Hall, Detroit, MI 48201, United States. cl@med.wayne.edu
Telephone: +1-313-5774182 Fax: +1-313-5772765
Received: September 5, 2015
Peer-review started: September 8, 2015
First decision: October 16, 2015
Revised: October 21, 2015
Accepted: December 18, 2015
Article in press: December 21, 2015
Published online: March 15, 2016
Core Tip

Core tip: The present review aimed to analyze most published data regarding the emerging role of cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel in many tissues and organs, in various cancers, with the focus on the link between CFTR dysfunction and gastrointestinal cancers. The possible underlying mechanisms have also been discussed.