Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2025; 17(8): 109743
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.109743
Clinical characteristics and diagnostic factors of tumor-associated acute pancreatitis: A comparative analysis of early vs delayed diagnosis
Chuan-Chao Xia, Long-Gui Ning, Yue Xu, Guo-Qiang Xu
Chuan-Chao Xia, Long-Gui Ning, Yue Xu, Guo-Qiang Xu, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Co-first authors: Chuan-Chao Xia and Long-Gui Ning.
Author contributions: Xia CC wrote the manuscript; Xia CC, Ning LG and Xu Y contributed to the data collection and analysis; Xu GQ contributed to the methodology and revising the manuscript; All authors have read and approve the final manuscript.
Supported by the National Natural Science Foundation of China, No. 8217030254.
Institutional review board statement: The study was approved by the Clinical Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine (No. IIT2025016B).
Informed consent statement: Written informed consent was applied for exemption considering the retrospective study design.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets analyzed in this study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Qiang Xu, Professor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1193065@zju.edu.cn
Received: May 21, 2025
Revised: May 28, 2025
Accepted: June 23, 2025
Published online: August 15, 2025
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Core Tip

Core Tip: Although pancreatic malignancies represent a relatively infrequent etiology of acute pancreatitis (AP), their association with adverse clinical outcomes necessitates prompt diagnostic evaluation. In this retrospective cohort study, significant differences in clinical characteristics, disease progression, and healthcare utilization were observed between the early and delayed diagnosis patients. Multivariable logistic analysis indicated that advanced age, pre-existing diabetes mellitus, hyperbilirubinemia, and concurrent with conventional AP etiologies are key high-risk indicators for occult pancreatic malignancy in tumor-associated AP patients.