Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 106393
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.106393
Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly patients with colorectal cancer
Shuai-Bo Qiao, Ming-Liao Niu, Wei-Tao Liang, Long-Jiang Zhang, Xiang Chen, Ying-Kun Zhu
Shuai-Bo Qiao, Xiang Chen, Ying-Kun Zhu, Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
Ming-Liao Niu, Wei-Tao Liang, Long-Jiang Zhang, Department of Anorectal Surgery, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450000, Henan Province, China
Author contributions: Qiao S and Niu ML designed the research study; Liang WT and Zhang LJ performed the research; Chen X and Zhu YK conducted experiments and analyzed the data; All authors contributed to editorial changes in the manuscript and read and approved the final manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of Henan Province Hospital of Traditional Chinese Medicine and complied with the principles and ethical requirements of the Declaration of Helsinki (No. HN-TCU2023-17).
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long-Jiang Zhang, Chief Physician, Department of Anorectal Surgery, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Zhengzhou 450000, Henan Province, China. hnszyyzlj@163.com
Received: March 12, 2025
Revised: April 3, 2025
Accepted: April 25, 2025
Published online: June 15, 2025
Processing time: 93 Days and 5.8 Hours
Core Tip

Core Tip: Elevated serum S100 calcium-binding protein A12 and soluble receptor for advanced glycation end products in elderly patients with colorectal cancer reflected gut microbiome dysbiosis and systemic inflammation that was driven by interleukin-6/tumor necrosis factor-α signaling. Their post-chemotherapy decline parallels microbiota restoration, supporting a microbiome-inflammation-biomarker axis. The combined biomarker model offers robust clinical utility for chemotherapy efficacy prediction and personalized therapeutic strategies.