Role, mechanism, and application of N6-methyladenosine in hepatobiliary carcinoma

doi:10.4251/wjgo.v17.i6.105140

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105140
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105140

Role, mechanism, and application of N6-methyladenosine in hepatobiliary carcinoma

Chen Jia, Qing-Fu Lang, Zhi-Jie Yin, Jia Sun, Qing-Hui Meng, Tie-Min Pei

Chen Jia, Qing-Fu Lang, Zhi-Jie Yin, Jia Sun, Qing-Hui Meng, Tie-Min Pei, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China

Author contributions: Jia C, Lang QF conceived, wrote, and edited the manuscript; Yin ZJ and Sun J prepared figures; Yin ZJ, Sun J, Meng QH and Pei TM provided significant assistance; All authors read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 82172792.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Tie-Min Pei, Chief Physician, Professor, Senior Researcher, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Postal Street, Nangang District, Harbin 150001, Heilongjiang Province, China. tiemin2008@163.com

Received: January 13, 2025
Revised: April 1, 2025
Accepted: April 22, 2025
Published online: June 15, 2025
Processing time: 152 Days and 3.5 Hours

Core Tip

Core Tip: N6-methyladenine (m6A) modifications is one of the most common RNA modifications in eukaryotes, and it has been reported to affect biological process of cells via regulation of gene expression, and play a crucial role in occurrence and development in various cancers by regulating RNA stability, decay, spicing and transport. This article summarized the role and mechanism of m6A modification in hepatobiliary carcinoma, and discussed its potential clinical application in an attempt to provide theoretical evidences for the individualized treatment of hepatobiliary carcinoma.