Qiu TH, Wen HY, Huang YL. Significance of hemoglobin and hematocrit changes in predicting patient survival and efficacy of neoadjuvant chemotherapy for advanced gastric cancer. World J Gastrointest Oncol 2025; 17(6): 104592 [DOI: 10.4251/wjgo.v17.i6.104592]
Corresponding Author of This Article
Ti-Hong Qiu, MD, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, No. 666 Section 2 Deyuan North Road, Chengdu 611730, Sichuan Province, China. 19382136238@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 104592 Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.104592
Significance of hemoglobin and hematocrit changes in predicting patient survival and efficacy of neoadjuvant chemotherapy for advanced gastric cancer
Ti-Hong Qiu, Hong-You Wen, Yi-Long Huang
Ti-Hong Qiu, Hong-You Wen, Yi-Long Huang, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, Chengdu 611730, Sichuan Province, China
Author contributions: Qiu TH designed the research and wrote the first manuscript; Qiu TH and Wen HY contributed to conceiving the research and analyzing data; Qiu TH and Huang YL conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital.
Informed consent statement: Patients were not required to provide informed consent for this study, as the analysis used anonymized clinical data that were collected after each patient had provided written consent for treatment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ti-Hong Qiu, MD, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, No. 666 Section 2 Deyuan North Road, Chengdu 611730, Sichuan Province, China. 19382136238@163.com
Received: March 7, 2025 Revised: March 31, 2025 Accepted: April 24, 2025 Published online: June 15, 2025 Processing time: 97 Days and 18.5 Hours
Core Tip
Core Tip: The prevalence of anemia in patients with cancer is well documented. Abnormal erythrocyte pressure levels cause tumor hypoxia, which leads to changes in tumor-associated proteins and accelerates tumor cell proliferation. These factors are closely related to the efficacy of chemotherapy and overall prognosis. Reduced hemoglobin levels indicate the presence of anemia, which aggravates disease progression, reduces nutrient absorption, affects the hematopoietic capacity of the bone marrow, reduces renal function, and results in poor prognosis. This study analyzes the prognostic significance of changes in hemoglobin and erythrocyte levels on the effects of neoadjuvant chemotherapy and survival rates of patients with advanced gastric cancer.
