Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2025; 17(5): 104686
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104686
SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways
Peng Peng, Juan Sun, Meng-Shi Li, Ruo-Xi Cheng, Shi-Quan Liu, Meng-Bin Qin, Jin-Xiu Zhang, Jie-An Huang
Peng Peng, Juan Sun, Meng-Shi Li, Ruo-Xi Cheng, Shi-Quan Liu, Meng-Bin Qin, Jin-Xiu Zhang, Jie-An Huang, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China
Co-first authors: Peng Peng and Juan Sun.
Co-corresponding authors: Jin-Xiu Zhang and Jie-An Huang.
Author contributions: Peng P, Sun J, Li MS, Zhang JX, and Huang JA developed the original hypothesis and supervised the experimental design; Peng P, Zhang JX, Li MS, and Qin MB performed the experiments; Sun J, Cheng RX and Liu SQ participated in the clinical specimens collection; Sun J, Zhang JX, Liu SQ and Qin MB analyzed the data and performed statistical analysis; Peng P, Sun J, Zhang JX, and Huang JA wrote and revised the manuscript; All authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Guangxi Province, No. 2019GXNSFAA185030 and No. 2023GXNSFBA026129; the Scientific Research Project of the Second Affiliated Hospital of Guangxi Medical University, No. EFYKY2020013; and the Cultivation Science Foundation of the Second Affiliated Hospital of Guangxi Medical University, No. GJPY2023005 and No. GJPY2023009.
Institutional review board statement: The study was reviewed and approved by the second Affiliated Hospital of Guangxi Medical University Institutional Review Board (No. KY-0231).
Institutional animal care and use committee statement: No animal experiments were performed in this study and therefore no animals were used.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie-An Huang, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxue East Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. hjagxmu@163.com
Received: December 31, 2024
Revised: March 11, 2025
Accepted: April 10, 2025
Published online: May 15, 2025
Processing time: 135 Days and 17.8 Hours
Core Tip

Core Tip: The SPDL1 is a gene involved in cell cycle regulation and influences the development of a variety of tumours, including colorectal cancer (CRC). In this study, we investigated the effect of SPDL1 on CRC. We found that interference with SPDL1 expression promoted CRC proliferation, migration and invasion, suggesting that SPDL1 may have a potential tumour suppressor role in CRC by inducing epithelial-mesenchymal transition and by mechanistically targeting the epidermal growth factor receptor/extracellular signal-regulated kinase pathway.