Wang Q, Zhang XY, Yang JF, Tao YL. Comparison of dynamic contrast-enhanced-magnetic resonance imaging parameters and serum markers in preoperative rectal cancer evaluation: Combined diagnostic value. World J Gastrointest Oncol 2025; 17(5): 103809 [DOI: 10.4251/wjgo.v17.i5.103809]
Corresponding Author of This Article
Qun Wang, Department of Radiology, The First People’s Hospital of Jiashan, No. 1218 South Sports Road, Luoxing Street, Jiaxing 314000, Zhejiang Province, China. wangqun330823@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2025; 17(5): 103809 Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.103809
Comparison of dynamic contrast-enhanced-magnetic resonance imaging parameters and serum markers in preoperative rectal cancer evaluation: Combined diagnostic value
Qun Wang, Xin-Yu Zhang, Jing-Fei Yang, Yi-Lei Tao
Qun Wang, Xin-Yu Zhang, Jing-Fei Yang, Yi-Lei Tao, Department of Radiology, The First People’s Hospital of Jiashan, Jiaxing 314000, Zhejiang Province, China
Co-first authors: Qun Wang and Xin-Yu Zhang.
Author contributions: Wang Q and Zhang XY jointly conceptualized and designed the research, conducted data analyses, and drafted the manuscript; Yang JF and Tao YL were primarily responsible for data collection and preprocessing, and assisted in data analysis and discussion; All authors reviewed and edited the manuscript; Wang Q and Zhang XY are co-first authors, and Wang Q serves as the corresponding author, overseeing the overall coordination and supervision of the project.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The First People’s Hospital of Jiashan, Zhejiang Province, with the approval number 2024 Research Ethics Approval No. 097. All procedures followed in this study were in accordance with the ethical standards of the hospital’s review board and the principles of the Declaration of Helsinki, as well as applicable national research regulations.
Informed consent statement: Informed consent was not required for this retrospective study, as it involved the analysis of previously collected clinical data and imaging results.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Due to privacy and ethical considerations, data are not publicly available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qun Wang, Department of Radiology, The First People’s Hospital of Jiashan, No. 1218 South Sports Road, Luoxing Street, Jiaxing 314000, Zhejiang Province, China. wangqun330823@163.com
Received: December 13, 2024 Revised: January 23, 2025 Accepted: February 27, 2025 Published online: May 15, 2025 Processing time: 152 Days and 16.2 Hours
Core Tip
Core Tip: This study evaluates the diagnostic efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters (volume transfer constant, volume fraction of extravascular extracellular space) and serum tumor markers [carbohydrate antigen (CA) 19-9, CA125] in rectal cancer. Results show that combined analysis significantly improves accuracy in assessing T staging and differentiation degree, surpassing individual methods. DCE-MRI captures tumor microenvironment characteristics, while serum markers reflect systemic tumor activity, providing complementary insights. The combined approach achieved area under the curves of 0.923 and 0.912 for T staging and differentiation, respectively, highlighting its clinical utility. These findings suggest that integrating functional imaging with serum biomarkers can enhance preoperative assessment and guide individualized treatment strategies for rectal cancer.
