Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 2006-2017
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2006
METTL5 promotes cell proliferation, invasion, and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer
Ling-Shang Kong, Ran Tao, Yi-Fan Li, Wen-Bin Wang, Xue Zhao
Ling-Shang Kong, Ran Tao, Yi-Fan Li, Wen-Bin Wang, Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China
Ling-Shang Kong, Ran Tao, Yi-Fan Li, Wen-Bin Wang, Department of Vascular Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230002, Anhui Province, China
Wen-Bin Wang, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China
Wen-Bin Wang, Anhui Public Health Clinical Center, Hefei 230012, Anhui Province, China
Xue Zhao, Department of Scientific Research, Anhui Public Health Clinical Center, Hefei 230012, Anhui Province, China
Xue Zhao, Department of Scientific Research, The First Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China
Co-corresponding authors: Wen-Bin Wang and Xue Zhao.
Author contributions: Kong LS, Tao R, and Li YF collected the data, performed the experiments and statistical analysis, and wrote the manuscript; Wang WB and Zhao X designed the study and performed quality control. Kong LS and Tao R contributed equally to this work. Wang WB and Zhao X made outstanding contributions to this study as co-corresponding authors.
Supported by Natural Science Foundation in Anhui Province of China, No. 2008085MH279; and Key Project of Anhui Translational Medicine Research Institute, No. 2022zhyx-B08.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Anhui Medical University Institutional Review Board (approval No. 190278).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data are available upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue Zhao, MM, Department of Scientific Research, Anhui Public Health Clinical Center, No. 100 Huaihai Avenue, Hefei 230012, Anhui Province, China. 472959583@qq.com
Received: September 13, 2023
Peer-review started: September 13, 2023
First decision: December 14, 2023
Revised: January 10, 2024
Accepted: March 18, 2024
Article in press: March 18, 2024
Published online: May 15, 2024
Core Tip

Core Tip: N6-methyladenosine is one of the most common post-transcriptional RNA modifications in mammals and one of the major methylation modifications in mRNA and non-coding RNAs, which can affect RNA splicing, translation, stability, and epigenetic effects of certain non-coding RNAs. This is the first fundamental study to examine the role of METTL5 in colorectal cancer (CRC), which is important for understanding the impact of the METTL family on the development of CRC.