Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2023; 15(4): 617-631
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.617
Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy
Xiao-Chen Feng, Fu-Chen Liu, Wu-Yu Chen, Jin Du, Hui Liu
Xiao-Chen Feng, Fu-Chen Liu, Wu-Yu Chen, Jin Du, Hui Liu, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200082, China
Author contributions: Liu H constructed the idea of the article; Feng XC, Liu FC, Chen WY and Du J wrote the manuscript; Liu H, Feng XC and Liu FC revised the paper; Liu H provided financial support.
Supported by National Natural Science Foundation of China, No. 81970453, and No. 82270634; and Shanghai Science and Technology Innovation Action Plan Project, No. 20XD1405100.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui Liu, MD, PhD, Chief Doctor, Professor, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, Shanghai 200082, China. liuhuigg@hotmail.com
Received: December 4, 2022
Peer-review started: December 4, 2022
First decision: December 26, 2022
Revised: January 9, 2023
Accepted: March 8, 2023
Article in press: March 8, 2023
Published online: April 15, 2023
Core Tip

Core Tip: This review systematically summarizes the aberrant changes of lipid metabolism in hepatocellular carcinoma (HCC), and for the first time expounds the impact of lipid metabolism on HCC targeted therapy and immunotherapy. It vividly displayed the changes of lipid metabolism in HCC and the targets of some reagents by drawing figures, and summarized the impact of lipid metabolism related reagents on HCC targeted therapy and immunotherapy through table.