Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2023; 15(3): 523-532
Published online Mar 15, 2023. doi: 10.4251/wjgo.v15.i3.523
Risk of pancreatic cancer in individuals with celiac disease in the United States: A population-based matched cohort study
Arunkumar Krishnan, Yousaf Bashir Hadi, Sarah Shabih, Diptasree Mukherjee, Ruhee A Patel, Rushik Patel, Shailendra Singh, Shyam Thakkar
Arunkumar Krishnan, Yousaf Bashir Hadi, Sarah Shabih, Ruhee A Patel, Rushik Patel, Shailendra Singh, Shyam Thakkar, Section of Gastroenterology & Hepatology, West Virginia University School of Medicine, Morgantown, WV 26505, United States
Diptasree Mukherjee, Department of Medicine, Apex Institute of Medical Science, Kolkata 700075, West Bengal, India
Author contributions: Krishnan A conceptualized and designed the research and performed the formal analysis and interpretation of the data; Krishnan A and Hadi YB wrote the original draft and performed the review and editing of the draft; Krishnan A performed a critical revision of the manuscript; and all authors revised the manuscript for important intellectual content and approved the article’s final version, including the authorship list.
Institutional review board statement: TriNetX data have been granted a waiver from the Western institutional review board as a federated network since only aggregated counts and statistical summaries of de-identified information.
Informed consent statement: Not applicable for de-identified data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE-Statement checklist of items, and the manuscript was prepared and revised according to the STROBE-Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Arunkumar Krishnan, MBBS, Doctor, Section of Gastroenterology & Hepatology, West Virginia University School of Medicine, PO Box 9161, 5th Floor HSC, Room 5500, Morgantown, WV 26505, United States.
Received: November 11, 2022
Peer-review started: November 11, 2022
First decision: November 28, 2022
Revised: December 8, 2022
Accepted: February 10, 2023
Article in press: February 10, 2023
Published online: March 15, 2023
Core Tip

Core Tip: Celiac disease (CD) is an immune-mediated disorder precipitated by the ingestion of gluten in genetically predisposed individuals. Population-based studies have shown the risk of cancer among patients with CD; however, the magnitude of the risk of pancreatic cancer (PC) in association with CD is much less clear. Therefore, In this multicenter retrospective cohort study, we analyzed the risk of PC in patients with CD. We examined the incidence of PC in patients with CD compared with a propensity-matched cohort of patients without CD. We found that patients with CD were at increased risk of PC. Risk elevation persisted beyond the first year after diagnosis to reference individuals without CD from the general population.