Gao HL, Lv LB, Zhao WF, Lu QW, Fan JQ. Diagnostic accuracy of the multi-target stool DNA test in detecting colorectal cancer: A hospital-based study. World J Gastrointest Oncol 2023; 15(1): 102-111 [PMID: 36684047 DOI: 10.4251/wjgo.v15.i1.102]
Corresponding Author of This Article
Jin-Qing Fan, PhD, Doctor, Department of Traditional Chinese Medicine, The Affiliated Hospital of Medical School of Ningbo University, No. 247 Renmin Road, Ningbo 315000, Zhejiang Province, China. 824803804@qq.com
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Gastroenterology & Hepatology
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research-article
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Gao HL, Lv LB, Zhao WF, Lu QW, Fan JQ. Diagnostic accuracy of the multi-target stool DNA test in detecting colorectal cancer: A hospital-based study. World J Gastrointest Oncol 2023; 15(1): 102-111 [PMID: 36684047 DOI: 10.4251/wjgo.v15.i1.102]
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 102-111 Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.102
Diagnostic accuracy of the multi-target stool DNA test in detecting colorectal cancer: A hospital-based study
Han-Lu Gao, Le-Bin Lv, Wang-Fang Zhao, Qi-Wen Lu, Jin-Qing Fan
Han-Lu Gao, Le-Bin Lv, Department of Preventive Health, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang Province, China
Wang-Fang Zhao, Qi-Wen Lu, Department of Gastroenterology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315000, Zhejiang Province, China
Jin-Qing Fan, Department of Traditional Chinese Medicine, The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315000, Zhejiang Province, China
Author contributions: Gao HL performed data analysis and wrote the manuscript; Zhao WF and Lu QW participated in the collection of human material; Lv LB performed data collection and collation; Fan JQ designed the study and corrected the manuscript.
Supported byThe Health Science and Technology Project of Zhejiang Province, No. 2021KY1048 and No. 2022KY1142; The Ningbo Health Young Technical Backbone Talents Training Program, No. 2020SWSQNGG-02; Key Science and Technology Project of Ningbo City, No. 2021Z133.
Institutional review board statement: The study was approved by the Human Research and Ethics Committee of the Affiliated Hospital of Medical School of Ningbo University (Approval No. KY20201111).
Informed consent statement: Informed written consent was obtained from the patient and her family for publication of this report and any accompanying images.
Conflict-of-interest statement: No conflict of interest exists in the submission of this manuscript.
Data sharing statement: No additional data are available.
Corresponding author: Jin-Qing Fan, PhD, Doctor, Department of Traditional Chinese Medicine, The Affiliated Hospital of Medical School of Ningbo University, No. 247 Renmin Road, Ningbo 315000, Zhejiang Province, China. 824803804@qq.com
Received: September 17, 2022 Peer-review started: September 17, 2022 First decision: November 18, 2022 Revised: November 19, 2022 Accepted: December 21, 2022 Article in press: December 21, 2022 Published online: January 15, 2023 Processing time: 114 Days and 20.1 Hours
Core Tip
Core Tip: The sensitivity and specificity for colorectal cancer (CRC) detection were 90.2% and 83.3%, respectively, with an accuracy of 89.8%. For adenoma, the sensitivity and specificity were 56.5% and 68.9%, respectively, with an accuracy of 73.1%. The multi-target stool DNA (MT-sDNA) test showed better performance for the detection of CRC, which was superior to alpha-fetoprotein, carcinoembryonic antigen (CEA), and carbohydrate antigen 199 separately, but not for predicting adenomas. The sensitivity and specificity of MT-sDNA combined with CEA in the diagnosis of adenoma were 78.3% and 60.7%, respectively, which suggested that combined detection has certain advantages in adenoma diagnosis. This study can help clinicians select a standardized and optimal management strategy for the treatment of these patients.
