Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2022; 14(3): 587-606
Published online Mar 15, 2022. doi: 10.4251/wjgo.v14.i3.587
Gut and liver involvement in pediatric hematolymphoid malignancies
Umeshreddy V Devarapalli, Moinak S Sarma, Gopinathan Mathiyazhagan
Umeshreddy V Devarapalli, Moinak S Sarma, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Gopinathan Mathiyazhagan, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Author contributions: Devarapalli UV, Sarma MS and Mathiyazhagan G contributed to the literature review; Devarapalli UV and Mathiyazhagan G contributed to the primary drafting; Sarma MS reviewed concept and design, intellectual inputs, and final drafting.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Moinak S Sarma, MD, Associate Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. moinaksen@yahoo.com
Received: September 3, 2021
Peer-review started: September 3, 2021
First decision: October 3, 2021
Revised: October 22, 2021
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: March 15, 2022
Core Tip

Core Tip: Pediatric hematolymphoid malignancies commonly are leukemias, lymphomas, and Langerhans cell histiocytosis. Their gut and liver involvement are seldom discussed due to a lack of literature in children. Manifestations result from infiltration, compression, overwhelmed immune system, and chemotherapy-induced drug toxicities. In this review, we will discuss the diverse abdominal manifestations and challenges from a pediatric gastroenterologist’s perspective.