Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2266-2272
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2266
Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon: A case report
Hyeon Seok Baek, Sang Wook Kim, Soo Teik Lee, Ho Sung Park, Seung Young Seo
Hyeon Seok Baek, Sang Wook Kim, Soo Teik Lee, Seung Young Seo, Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju-si 56445, Jeollabuk-do, South Korea
Ho Sung Park, Department of Pathology, Jeonbuk National University Medical School, Jeonju-si 56445, Jeollabuk-do, South Korea
Author contributions: Baek HS analyzed clinical data and drafted the manuscript; Lee ST, Kim SW, Seo SY advised and reviewed the manuscript; Park HS performed the pathologic review.
Informed consent statement: Informed written consent was obtained from the patient regarding the publication of this report and accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seung Young Seo, MD, PhD, Professor, Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si 56445, Jeollabuk-do, South Korea. bear7905@jbnu.ac.kr
Received: July 22, 2022
Peer-review started: July 22, 2022
First decision: August 19, 2022
Revised: August 31, 2022
Accepted: October 12, 2022
Article in press: October 12, 2022
Published online: November 15, 2022
Core Tip

Core Tip: Large cell neuroendocrine carcinoma (LCNEC) account for about 0.25% of colorectal cancer patients. Furthermore, LCNEC with synchronous or metachronous adenocarcinoma in the colon has been reported in only a few cases. We report the diagnostic experience of a 62-year-old patient with advanced LCNEC in the colon and synchronous adenocarcinoma metastasis but no definitive symptoms except anemia. We suggest the possibility of an association between the two types of primary colon cancer. Therefore, if a patients diagnosed with LCNEC in the colon, appropriate screening tests are required. Further studies are needed on the pathogenesis of the two primary cancers.