Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2021; 13(4): 265-278
Published online Apr 15, 2021. doi: 10.4251/wjgo.v13.i4.265
Published online Apr 15, 2021. doi: 10.4251/wjgo.v13.i4.265
Expression profiles of gastric cancer molecular subtypes in remnant tumors
Marcus Fernando Kodama Pertille Ramos, Marina Alessandra Pereira, Ulysses Ribeiro Jr, Bruno Zilberstein, Ivan Cecconello, Department of Gastroenterology, Instituto do Cancer, Hospital das Clinicas, HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01249000, São Paulo, Brazil
Leonardo Cardili, Evandro Sobroza de Mello, Department of Pathology, Instituto do Cancer, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01249000, São Paulo, Brazil
Author contributions: Ramos MFKP and Pereira MA contributed to study design, data retrieval, critical analysis, and draft of the manuscript; Cardili L and de Mello ES contributed to data retrieval and pathological analysis; Ribeiro Jr U, Zilberstein B and Cecconello I contributed to critical analysis and review of the manuscript.
Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo , No. 2016/25524-0 .
Institutional review board statement: The study was approved by the Hospital das Clínicas da Faculdade de Medicina da USP Ethics Committee and registered online (https://plataformabrasil.saude.gov.br; CAAE: 37009120
Informed consent statement: Informed consent was waived by the local Ethics Committee because of the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marina Alessandra Pereira, MSc, Research Scientist, Department of Gastroenterology, Instituto do Cancer, Hospital das Clinicas, HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 251 Av Dr Arnaldo, São Paulo 01249000, São Paulo, Brazil. marina.pereira@hc.fm.usp.br
Received: December 23, 2020
Peer-review started: December 23, 2020
First decision: February 14, 2021
Revised: February 16, 2021
Accepted: March 22, 2021
Article in press: March 22, 2021
Published online: April 15, 2021
Peer-review started: December 23, 2020
First decision: February 14, 2021
Revised: February 16, 2021
Accepted: March 22, 2021
Article in press: March 22, 2021
Published online: April 15, 2021
Core Tip
Core Tip: This is a retrospective study to evaluate the molecular subtypes of gastric cancer (GC) using a panel by immunohistochemistry and in situ hybridization in remnant GC (RGC). We also compared the RGC patients with primary GC (PGC) to investigate whether the expression profiles were different between both types of GC. The findings indicated that RGC was associated with the Epstein-Barr virus. RGC also exhibited higher rates of simultaneous changes in two or more profiles compared to PGC. However, molecular subtypes of GC had no significant prognostic impact in terms of survival in RGC patients.