Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2021; 13(4): 252-264
Published online Apr 15, 2021. doi: 10.4251/wjgo.v13.i4.252
Predictive factors for early distant metastasis after neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Hyojung Park
Hyojung Park, Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 46115, South Korea
Author contributions: Park H analyzed the data and wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Dankook University Hospital.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no conflicts to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hyojung Park, MD, Doctor, Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, 201 Manghyang-ro, Dongnam-gu, Cheonan 46115, South Korea.
Received: September 10, 2020
Peer-review started: September 10, 2020
First decision: November 3, 2020
Revised: January 11, 2021
Accepted: March 16, 2021
Article in press: March 16, 2021
Published online: April 15, 2021
Core Tip

Core Tip: This is a retrospective study to investigate prognostic factors for distant metastasis, especially early distant metastasis, using the standard treatment paradigm to identify the most effective treatments according to recurrence risk. Poorly differentiated tumors, involvement of mesorectal fascia, or presence of extramural involvement were associated with distant metastasis and early distant metastasis. For patients with these risk factors, early systemic chemotherapy could be beneficial. Selective use of neoadjuvant treatment other than the current standard treatment according to individualized risk factors is necessary.