Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2021; 13(2): 131-146
Published online Feb 15, 2021. doi: 10.4251/wjgo.v13.i2.131
Outcomes of curative esophageal cancer surgery in elderly: A meta-analysis
Nikolaj S Baranov, Cettela Slootmans, Frans van Workum, Bastiaan R Klarenbeek, Yvonne Schoon, Camiel Rosman
Nikolaj S Baranov, Cettela Slootmans, Frans van Workum, Bastiaan R Klarenbeek, Camiel Rosman, Department of Surgery, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands
Yvonne Schoon, Department of Geriatrics, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands
Author contributions: All authors contributed to the design of the work, Baranov NS, Slootmans C and van Workum F were involved in acquisition of the data; analysis was performed by Baranov NS and all other authors were involved in interpretation of the work; Baranov NS and Slootmans C were involved in drafting the manuscript; all other authors were involved in critically revising the manuscript for intellectual content. All authors approve of the version to be published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikolaj S Baranov, BSc, Department of Surgery, Radboud University Medical Center, Geert Grooteplein 10/Postal box 9101, Nijmegen 6525GA, the Netherlands. nikolaj.baranov@radboudumc.nl
Received: September 22, 2020
Peer-review started: September 22, 2020
First decision: November 16, 2020
Revised: November 29, 2020
Accepted: December 11, 2020
Article in press: December 11, 2020
Published online: February 15, 2021
Core Tip

Core Tip: In this systematic review including articles from the last 25 years, it was found that older esophageal cancer patients suffer from a two-fold higher risk of in-hospital and 90-d mortality as compared to their younger counterparts. In addition, subgroup analysis showed that these differences did not occur when only studies on minimally invasive esophagectomy were analyzed. This implies that minimally invasive esophagectomy may be important for minimizing morbidity and mortality in older patients undergoing curative esophagectomy.