Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2020; 12(9): 1044-1055
Published online Sep 15, 2020. doi: 10.4251/wjgo.v12.i9.1044
Oncological outcomes and predictors of radiofrequency ablation of colorectal cancer liver metastases
Chuan-Zhuo Wang, Guang-Xin Yan, He Xin, Zhao-Yu Liu
Chuan-Zhuo Wang, Guang-Xin Yan, He Xin, Zhao-Yu Liu, Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang CZ and Liu ZY designed the research; Xin H and Yan GX performed the clinical research; Wang CZ, Xin H and Yan GX analyzed the data; Wang CZ and Liu ZY wrote the paper; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81470086 and No. 81871465.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University.
Informed consent statement: The patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this article.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhao-Yu Liu, MD, Chairman, Chief Doctor, Department of Radiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. liushjh@163.com
Received: May 6, 2020
Peer-review started: May 6, 2020
Revised: June 21, 2020
Accepted: August 15, 2020
Article in press: August 15, 2020
Published online: September 15, 2020
Core Tip

Core Tip: Relatively high rate of local tumor progression (LTP) is an obstacle to more widespread use of radiofrequency ablation (RFA) in colorectal cancer liver metastasis (CRLM) patients. The purpose of this retrospective study was to determine the oncological outcomes and predictors of RFA in CRLM patients. The median overall survival (OS) of the 85 patients was 36 mo, and the rate of LTP was 32.6% in 138 lesions. Multivariate analysis showed that tumor size and ablative margin were independent predictors of LTP-free survival, while tumor number, tumor size, and extrahepatic disease were independent predictors of OS.